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desvenlafaxine will increase the stage or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Desvenlafaxine inhibits CYP2D6; with better desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by as many as fifty%; no dosage adjustment required with desvenlafaxine doses 7 consecutive days quickly p